Wednesday, December 22, 2004

Inre: Naproxen

With 70 incidents, no difference between Celebrex and the placebo, and a 50% increase in the risk between naproxen and placebo, the number of incidients attributed to Celebrez and the placebo is 20 and naproxen is 30.

As this conflicts with the recent news of Celebrex increasing the risk of cardiac incidents by 240%, there is clearly something else going on.

The answer is going to be difficult to find as the increased cardiac risk precludes further studies. With the conflicting data, there could as likely be no increased risk as there is risk.

Unfortunately, obtaining participiants is going to be difficult. Imagine asking someone to volunteeer for a study to see if a drug increases the risk of having a heart attack or stroke.

Of course, the sample could be drawn from those who are already in dire straits like the Alzheimer's patients in the naproxen one, but are these individuals, taken as a group, truly representative of the healthy population?

Comments: Post a Comment

This page is powered by Blogger. Isn't yours?